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M94A2886.TXT
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1994-10-25
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Document 2886
DOCN M94A2886
TI HIV-1/HTLV-1 coinfection is associated with a high frequency of
myelopathies.
DT 9412
AU Harrison LH; Schechter M; Vaz BP; McArthur JC; Johns Hopkins University.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):202 (abstract no. PB0237). Unique
Identifier : AIDSLINE ICA10/94369689
AB INTRODUCTION: Although in postmortem examinations myelopathies are found
in up to 30% of HIV-1 infected patients, their clinical correlates are
recognized far less frequently. How often myelopathies occur among
subjects with HTLV-1 and HIV coinfection is not known. OBJECTIVE: To
compare the frequency of clinically detectable myelopathies in patients
with HIV/HTLV-1 coinfection and in patients infected with HIV only.
METHODS: A sample of participants of a study of HIV/HTLV-1 coinfection
(JAMA 1994; 271:353-357) were submitted to a thorough neurologic
examination performed by a neurologist blinded to their HTLV-1
serostatus. RESULTS: 13 individuals with coinfection and 44 HIV
positive, HTLV seronegative controls (HIV single infection) were
evaluated. The two groups were similar in terms of age, sex, CD4 count
and CD4%. Among coinfected patients, 10 (77%) had evidence of
myelopathy, as opposed to 7 (16%) controls (OR = 18, p = 0.0008). Among
coinfected subjects, those with evidence of myelopathy had a higher CD4
percentage (29%) than those without myelopathy (17%, p = 0.06).
CONCLUSION: These data indicate that HIV/HTLV-1 coinfection is
associated with a high frequency of clinically detectable myelopathies.
The full spectrum of neurologic abnormalities associated with
coinfection, as well as the pathogenesis and natural history, remain to
be determined and warrant further investigation.
DE Human HIV Infections/*COMPLICATIONS HTLV-I Infections/*COMPLICATIONS
Leukocyte Count Neurologic Examination Spinal Cord
Diseases/*COMPLICATIONS/EPIDEMIOLOGY Support, Non-U.S. Gov't T4
Lymphocytes MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).